New findings on the role of calcium-sensing receptor in the treatment of bone and mineral homeostasis disorders
2013
Abstract
Several drugs are used in the treatment of disorders of bone mineral homeostasis, e.g. vitamin D (and its analogs), bisphosphonates, hormones, and minerals (calcium, phosphate, strontium). The present article focuses mainly on drugs that affect the calcium-sensing receptor (CaSR) to decrease the secretion of parathormone and reduce Ca2+ concentration in serum.
Because allosteric modulators of CaSR (e.g. calcimimetics) have a potential to be clinically used in the treatment of bone disorders, the importance of experimental research directed toward the explanation of CaSR signal pathways is also discussed in this article.