TP53 mutations in myelodysplastic syndrome is significantly correlated with deletion of the long arm 5.chromozomu (5q-) and usually has a negative prognostic value (meaning TP53 examination in the era of lenalidomide)

Abstract

Mutations in tumor suppressor gene TP53 is studied in oncology and hematology for over 20 years. For most diseases have a negative prognostic significance ....

TP53 mutation is usually associated with MDS with complex karyotype changes with aberrations -7/7q ...

Keywords

• mutation myelodysplastic
• syndrome deletions of the long arm 5.chromozomu
• 5q-, TP53
• lenalidomide