Abstract
Obesity and overweight negatively affect the ability of women to conceive naturally, contributes to the increased incidence of obstetric complications during pregnancy and affect the outcome of assisted reproduction techniques (ART). The aim of our study was to compare the results of treatment of infertility in a group of infertile women undergoing ART, depending on the values of BMI and changes in levels of selected hormones and markers of oxidative stress in follicular fluid.
The studied group consisted of 44 women (mean age of 31.9 years, SD = 4.35) treated for infertility at the Institute of Reproductive Medicine and Endocrinology - IVF Centers Prof. Zech.
Women were divided into 2 groups according to BMI (37 women had normal BMI, with 7 women were overweight). Prolactin, free T3 (fT3) and T4 (FT4) hormone, homocysteine (Hcy), malondialdehyde (MDA), glutathione peroxidase (GPx), total antioxidant capacity (AOK) and total protein (CB) were analyzed in the FT both groups.
Only blood free samples were studied after pooling of all FF samples of each patient. We observed significantly lower levels of glutathione in the group of overweight women (p = 0.0044).
The pregnancy success rate with women with normal BMI and overweight women did not differ significantly from each other (p = 0.4430). Our study did not confirm the negative effect of obesity on the results of treatment of infertility, specifically pregnancy rate in a group of infertile women undergoing treatment with assisted reproduction techniques.