Synthesis of alkylcarbonate analogs of O-acetyl-ADP-ribose

Abstrakt

The non-hydrolyzable alkylcarbonate analogs of O-acetyl-ADP-ribose have been synthesized from the phosphorylated ribose derivatives after coupling with AMP morpholidate promoted by mechanical grinding. The analogs were assessed for their ability to inhibit the human sirtuin homolog SIRT1.

Klíčová slova

• deacetylases
• furanosides
• metabolite
• binding
• sites