Abstrakt
Immunoglobulin A (IgA) pemphigus is a clinically distinct variant of penphigus characterized by intercellular IgA deposition in the epidermis. Recently, an IgA/Immunoglobulin G (IgG) subset of penphigus with IgA and IgG anti-keratinocyte cell surface antibodies has been described.
Both IgA and IgA(IgG penphigus have been associated with internal malignancies. Above all, monoclonal IgA gammopathy in patients with IgA penphigus has been reported, and lung cancers in association with IgA/IgG pemphigus have been described.
IgA pepnpihus can be successfully treated with dapsone, whereas therapeutic management of IgG/igA pemphigus is not well established yet. We report a rare case of a patient, who developed atypical pemphigus with both IgA and IgG autoantibodies and an underlying lung cancer, successfully treated with corticosteroids and dapsone.