Preparation and Application of Monolithic Columns as Modern Separation Media

Abstract

This article provides basic information on monolithic columns for separation purposes. General characteristics of monolithic columns and their difference from common packed columns are described.

Preparation of monolithic columns, various effects on their morphological properties and possible applications are discussed, for both organic and silica monoliths.

Keywords

• performance liquid-chromatography
• ion-exchange chromatography
• silica capillary columns
• polymer monoliths
• macroporous polymers
• small molecules
• stationary phases
• porous materials
• surface-area