Systematic mutational analysis of the active-site threonine of HIV-1 proteinase: re-thinking the ?fireman´s grip? hypothesis

Abstrakt

Enzymologic and virologic examination of the 'fireman's girp' structure on several HIV-1 PR mutants.

Klíčová slova

• HIV-1 proteinase
• fireman's grip
• monomer
• dimer