Hydroxyethylamine Isostere of an HIV-1 Protease Inhibitor Prefers Its Amine to the Hydroxy Group in Binding to Catalytic Aspartates. A Synchrotron Study of HIV-1 Protease in Complex with a Peptidomimetic Inhibitor.

Abstract

An X-ray diffraction study of a structure of the complex of HIV-1 PR with a hydroxyethylamine containing inhibitor.

Keywords

• Crystallography
• HIV-1 protease
• inhibitor
• hydroxyethylamine