Pre- and postsynaptic effects of the calcium channel blocker Verapamil at neuromuscular junctions

Abstract

Experiments on the frog sartorius muscle were used to study the effects of the L-type calcium channel blocker verapamil on endplate currents. Verapamil had no effect on the amplitudes of miniature and multiple-quantum endplate currents, the synchronicity of transmitter secretion, or repeat activity in nerve endings.

Keywords

• Verapamil
• cholinoreceptors
• desensitization
• calcium
• channels