The paper is concerned with classification of amyloidosis and presenting clinical manifestations, examination metods and an effective diagnostic algorithm related to systemic AL amyloidisis. Greater attention is paid to current investigation techniques and their role in the differential diagnosis and stratification of systemic AL amyloidisis as a starting point for prognostic prediction and individual selection of therapy.
The review has been prepared in the light of the 2013 Czech Myeloma Group recommendations "Diagnosis and Treatment of Systemic AL Amyloidisis".