Effect of combining nicotinamide as a PARS-inhibitor with selective iNOS blockade during porcine endotoxemia

Abstract

To investigate the effects of combined selective inducible nitric oxide synthase (iNOS) inhibition using 1400 W with nicotinamide (NAD) as a PARS-inhibitor on hepato-splanchnic hemodynamics, O(2) kinetics, and energy metabolism during sepsis.