alpha-naphthoflavone acts as activator and reversible or irreversible inhibitor of rabbit microsomal CYP3A6

Abstract

Alpha-naphthoflavone is substrate of CYP3A6. It modulated oxidation of five known CYP3A6 substrate.

It could help for studiing of active center of CYP3A enzyme.

Keywords

• CST//Cytochrome P450
• modulation of enzyme activities
• mechanism-based inhibition
• activation
• metabolism