To the mechanism of 2-nitroanisole carcinogenicity: cytochrome P450-mediated metabolism of 2-nitroanisole

Abstract

While a cytochrome P450-mediated oxidation of 2-nitroanisole seems to be a detoxication pathway, its reductive activation led to formation of DNA adducts.

Keywords

• WRD//2-nitroanosole
• cytochrome P450
• detoxication
• reductases