Carcinogenic and nephrotoxic alkaloids aristolochic acids upon activation by D,T-diaphorase from adducts found in DNA of patients with chinese herbs nephropathy

Abstrakt

Aristolochic acid, a naturally occurring nephrotoxin and carcinogen, is implicated in a unique type of fibrosis, designated Chinese herbs nephropathy. This is the first report demonstrating an activation of aristolochic acid by D,T-diaphorase.

Klíčová slova

• CST//Aristolochic acid
• carcinogens
• activation
• D
• T-diaphorase
• DNA adducts