Carcinogenic and nephrotoxic alkaloids aristolochic acids are activated by D,T-diaphorase: 32P-postlabeling analysis of DNA adduct formation

Abstrakt

D,T-diaphorase possesses nitroreductase activity for naturally occurring nephrotoxic and carcinogenic nitrofenathrene derivative, aristolochic acid.

Klíčová slova

• CST//Aristolochic acids
• carcinogens
• D
• T-diaphorase
• DNA adducts
• 32P-postlabeling