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DNA adducts are formed from ellipticine and ellipticine-human serum albumin (Elli-HSA) in cells transfected with cytochrome P450

Publication at Faculty of Science |
2000

Abstract

Ellipticine is an antitumor drug interacting with DNA by intercalation. We demonstrate a covalent binding of this drug after its activation by CYPs in vitro,and in cells transfected with these enzymes