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CYP1A1/2 and prostaglandin H synthase catalyze reductive activation of inflammatory drug aristolochic acid and that results in DNA adduct formation

Publication at Faculty of Science |
2000

Abstract

Aristolochic acid (AA) is implicated in Chinese herbs nephropathy. CYP1A1/2 and prostaglandin H synthase are the major enzymes involved in reductive activation of AA.