Publication at First Faculty of Medicine |
2004
Abstract
The dopamine system is thought to play a crucial role in processing motivation and reward, and may also play a role in depression and anxiety disorders (especially social phobia). Interestingly, a range of antidepressants potentiate dopamine transmission in the nucleus accumbens.
Dopamine hypofunction may be particularly important in patients with psychomotor retardation and anhedonia. A range of evidence points to the involvement of the dopaminergic system in social phobia.
Dopaminergic agents, such as amisulpride or bupropion, in monotherapy or in combination with serotonergic agent s can help overcome pharmacoresistance in patients suffering from dysthymia, depression or anxiety disorders