1H NMR relaxivity of aqueous suspensions of titanium dioxide nanoparticles coated with a gadolinium(III) chelate of a DOTA-monoamide with a phenylphosphonate pendant arm

Abstract

Aryphosphonic acid DOTA derivative suitable for stable binding to metal oxide surface was prepared. Its Gd(III) complex was attached to nanocrystalline TiO2 surface.

The suspension has high relaxivity due to slow complex tumbling on oxide surface.

Keywords

• self-assembled monolayers
• MRI contrast agent
• lanthanide(III) complexes
• titania nanoparticles
• phosphonic acids
• relaxation
• NMRD
• titanium dioxide surface
• DOTA analog
• cell labelling