The activity of insulin-like growth factor and insulin-like growt factor binding proteins system is involved in pathogenesis of vascular damage in acromegalic patients

Abstract

The free-IGF-I serum levels are able to impair the function of microcirculation in acromegalic patients as measured by laser-doppler fluxmetry. The IGFBP-1 serum levels significantly correlate with those of total and LDL-cholesterol.