Abstract
Previously, we observed the association of Promyelocytic Leukaemia Nuclear Bodies (PML NBs) with Mouse Polyomavirus (MPyV) large tumorigenic antigen (LT) clusters in the nuclei of infected cells. We furher studied the involvement of PML NBs structural proteins PML, Daxx and Sp100 in that association and examined whether the polyomavirus profits by association with PML NBs or PML NBs are parts of defence mechanism against virus.
Also, the contribution of PML NBs to the viral genome maintenance based on the similar function towards to the cellular DNA was discussed.