Voltammetric and Amperometric Determination of N-Nitroso Antineoplastic Drugs at Mercury and Amalgam Electrodes
Abstract
Hanging mercury drop electrode and mercury meniscus modified silver solid amalgam electrode were used as electroanalytical sensors for voltammetric determination of antineoplastic drugs carmustine, lomustine and streptozotocin containing reducible N-nitroso group. On the example of carmustine it was shown that the one-step reduction occurs at substantially more negative potentials at amalgam electrode as compared with mercury electrode.
Both electrodes offer satisfactory repeatability of current response (relative standard deviations < 5 %) using DC voltammetry and differential pulse voltammetry. Achieved limits of determination lie mostly in the 10-7 mol l-1 concentration range.
Further, the mercury meniscus modified silver solid amalgam electrode was employed in "wall-jet" amperometric detection cell for determination of carmustine in flow injection analysis.