Oxidation of 3-aminobenzanthrone, a human metabolite of carcinogenic environmental pollutant 3-nitrobenzanthrone, by cytochromes P450 – similarity between human and rat enzymes

Abstract

Characterization of 3-aminobenzanthrone metabolites formed by rat hepatic microsomes containing cytochromes P450 (CYPs) and identification of the major rat and human CYPs participating in this process are aims of this study.

Keywords

• Oxidation
• 3-aminobenzanthrone
• human
• metabolite
• carcinogenic
• environmental
• pollutant
• 3-nitrobenzanthrone
• cytochromes
• P450
• human
• rat enzymes