Rat cytochromes P450 oxidize 2-nitrophenol, a human metabolite of carcinogenic 2-nitroanisole

Abstract

Characterization of the products of 2-nitrophenol metabolism by rat hepatic microsomes containing cytochromes P450 (CYPs) and identification of the major CYP enzymes participating in this process are aims of this study.

Keywords

• Rat
• cytochromes
• P450
• oxidize
• 2-nitrophenol
• human
• metabolite
• carcinogenic
• 2-nitroanisole