Histone deacetylase inhibitors valproate and trichostatin A are toxic to neuroblastoma cells and modulate cytochrome P450 1A1, 1B1 and 3A4 expression in these cells

Abstract

The cytotoxic effect of valproic acid and trichostatin A to human neuroblastoma UKF-NB-3, UKF-NB-4 and SK-N-AS cancer cell lines was investigated in this study. These HDCA inhibitors are cytotoxic to neuroblastomas and induce CYP 1A1 and 3A4 in some of these cells.

Keywords

• Histone deacetylase inhibitors
• valproate
• trichostatin A
• toxic
• neuroblastoma cells
• cytochrome P450 1A1
• 1B1
• 3A4
• expression