Genotoxic mechanisms for the carcinogenicity of the environmental pollutants and carcinogens o-anisidine and 2-nitroanisole follow from adducts generated by their metabolite N-(2-methoxyphenyl)-hydroxylamine with deoxyguanosine in DNA

Abstract

Both carcinogens, o-anisidine and 2-nitroanisole, are activated to the same proximate carcinogenic metabolite, N-(2-methoxyphenyl)hydroxylamine, which spontaneously decomposes to nitrenium and/or carbenium ions responsible for formation of deoxyguanosine adducts in DNA in vitro and in vivo.

Keywords

• genotoxic mechanism
• carcinogenicity
• environmental pollutant
• carcinogen
• o-anisidine
• 2-nitroanisole
• adduct
• metabolite
• N-(2-methoxyphenyl)-hydroxylamine
• deoxyguanosine
• DNA