Chemical and molecular basis of the carcinogenicity of Aristolochia plants

Abstract

The herbal drug aristolochic acid (AA) has been associated with the development of a novel nephropathy, designated as aristolochic acid nephropathy (AAN), and with human urothelial cancer.

Keywords

• Chinese herbs nephropathy
• balkan endemic nephropathy
• dna-adducts
• urothelial cancer
• salmonella-typhimurium
• acid nephropathy
• renal-failure
• p53 mutations
• risk-factor
• rats