Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III

Abstract

The study reports of several functional complexes of recombinant human GCPIII that allow for a direct comparison with equivalent GCPII complexes. That reveals differences in the organization of specificity pockets, in surface charge distribution, and in the occupancy of the co-catalytic zinc sites.

The data presented here provide information that should prove to be essential for the structurally- aided design of GCPIII-specific ligands.

Keywords

• GCPIII
• NAALADase II
• metallopeptidase