Does the Development of Urinary Dysfunction in Multiple Sclerosis Depend on the Type of Neurological Treatment?
Abstract
Multiple sclerosis (MS) is an auto-immune disease of the central nervous system. The course of the disease is benign (remittent) in 10 to 15 % of patients, but the degree of vesicouretral dysfunction does not correlate with a relatively favourable neurological finding.
Difficult micturition usually correlates with the degree of spastic paraparesis in the lower limbs. The objective of the prospective study was to assess the potential positive effect of neurological treatment with beta interferon on urinary dysfunction as compared with combined immunosuppressive therapy in patients with the same form of MS.
The group consisted of 98 patients with the remittent form of MS monitored from June 2002 to August 2006. Fifty patients were receiving combined immunosuppressive therapy, 48 patients were treated with first-choice drugs.
Based on urological and urodynamic examinations, the lower urinary tract dysfunction was treated according to generally accepted standards. The duration of the disease, the disease status at inclusion in the study, the trend in the neurological status during monitoring, the length of dysfunction of the lower urinary tract at inclusion in the study, the basic values of the initial and control urological examination, the type of dysfunction of the lower urinary tract, the urodynamic findings at baseline and during the follow up, the degree of post-micturition residual volume, as well as the subjective evaluation of the "success of the urological treatment" were evaluated.
No evidence of statistically significant improvement on the EDSS or in the quality of life was found in patients treated with first-choice drugs. Long-term follow up of such patients has shown a statistically significant decrease in the values of post-micturition residual volume and also their subjective perception of the urological treatment has become more positive.
First-choice therapy appears to be much better from the viewpoint of the prognosis for the dysfunction in the framework of the follow up of the incidence of the lower urinary tract disorder and of urological infection. Post-micturition residual volume has a crucial impact on the quality of life.
None of the above therapies has shown dependence of any of the criteria on patient age.