Effect of Surfactants and Ionic Strength on Dissociation of Hydrochlorides of Phenothiazine Derivatives
2009
Abstract
A study of the effect of the anionic surfactant dodecyl sulfate, the cationic surfactant carbethoxypentadecyl trimethyl ammonium bromide (Septonex), nonionic surfactant p-octyl phenyl polyoxyethylene (Triton X-100), and a strong electrolyte (KBr) on the dissociation of the hydrochlorides of two derivatives of phenothiazine (diethazine and fluphenazine) was made. It was found that sodium dodecyl sulfate increases the pKa value, whereas Septonex and Triton X-100 decrease this value.
The presence of KBr suppresses the effect of the surfactants. A new method for the potentiometric determination of fluphenazine in an aqueous medium was proposed.