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Highly enantioselective fluoromalonate addition to a,b-unsaturated aldehydes

Publication at Faculty of Science, First Faculty of Medicine, Faculty of Mathematics and Physics |
2009

Abstract

A highly enantioselective organocatalytic fluoromalonate addition to a,b-unsaturated aldehydes catalyzed by simple and commercially available secondary amines, affording the corresponding 1,4-adducts with high yields and enantioselectivities.