Comparison of the adsorption capacity and trapping effectiveness of diosmectite and charcoal on the compounds causing the 10 most frequent intoxications in acute medicine - the pilot study
Abstrakt
The project addresses still unsettled questions regarding the elimination step of medical treatment of acute intoxication, particularly the effectiveness of several commercially available adsorbers in the elimination process. Comparison of the adsorption capacity and trapping effectiveness of diosmectite and charcoal could be very important for the improvement of treatment procedures in cases of various acute intoxications.
The resolution of this subject will have unquestionable practical importance since there will be clear which adsorber is the best choice for treatment of particular intoxication. In some cases there could be even possible that mixture of both adsorbers will be recommended.
Such a comparison between commercially available adsorbers has not been published yet. However, it can definitely be beneficial for patients suffering acute intoxication in terms of better and more specific treatment in the elimination step of their therapy.
The model compounds causing the 10 most frequent intoxications in acute medicine in the Czech Republic were identified as following chemicals - benzodiazepines (e.g. diazepam), tricyclic antidepressants (e.g. dosulepin), carbamazepine, calcium channel blockers (e.g. amlodipine), non-steroidal anti-inflammatory drugs (e.g. ibuprofen), neuroleptics (e.g. promethazine), theophylline, barbiturates (e.g. phenobarbital), cardiac glycosides (e.g. digoxin) and alcohols (e.g. methanol). We will compare the properties of diosmectite and charcoal on the model compounds under various conditions in vitro.
We will use an artificial stomach-duodenum-intestine model. Such model conditions will differ mainly in pH values and will mimic the conditions in stomach, duodenum and intestine - the gastrointestinal tract compartments where adsorbers should work.
Additionally to research on the individual adsorbers the study on mixture of them will be performed in order to evaluate if they work in a synergic or antagonistic way.