Enhanced selectivity in CZE multi-chiral selector enantioseparation systems: Proposed separation mechanism
2010
Abstract
It has been reported many times that the commercial mixtures of chiral selectors (CS), namely highly sulfated beta-CDs (HS-beta-CDs), provide remarkable enantioselectivity in CZE when compared with single-isomer CDs, even single-isomer HS-beta-CDs. This enhanced enantioselectivity of multi-CS enantioseparative CZE is discussed in the light of multi-CS model that we have introduced earlier.
It is proposed on a theoretical basis and verified experimentally that the two enantiomers of a chiral analyte under interaction with a mixture of CSs are very likely to differ in their limit mobilities, which is opposite to single-CS systems where the two limit mobilities are likely to be the same.