Possible use of antioxidative enzymes and free radical's metabolites in the diagnostics of pain intensity
Abstract
In this study we try to find objective markers of pain intensity in the patients with chronic low back pain (dorsalgia and discopathia) using the final products of free radicals production malondialdehyde (MDA) and thiobarbituric acid reactive substances (TBARS) as well as the antioxidative enzymes superoxiddismutase (SOD) and glutathionperoxidase (GSHPx). It was found out that in patients with low back pain TBARS were increased in blood plasma.
The patients with dorsalgia had higher levels of SOD if compared with the control group. The levels of MDA and GSHPx did not differ significantly from the control group.
Our first results in patients with the low back pain confirmed some changes of the biochemical characteristics, which have been observed in animal's model of pain.