Publication at Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové |
2010
Abstract
Hepatocellular impairment associated with reduced biliary elimination of methotrexate may contribute to increased hepatotoxicity of the drug when co-administered with dexamethasone. Moreover, an influence of dexamethasone on protein expression of anionic drugs transporters in the liver and kidney was demonstrated.