Prolonged, selective inhibition of inducible nitric oxide synthase (iNOS) in intact rats by addition of L-N6-(1-iminoethyl)lysine (L-NIL) to drinking water

Abstract

Long-term treatment of experimental animals with non-selective inhibitors of all nitric oxide (NO) synthase (NOS) isoforms, such as NG-nitro-L-arginine methyl ester (L-NAME), has been used extensively to study chronic pathophysiological proces