Monitoring of minimal residual disease and mixed chimerism in a case of high-risk TEL/AML1-positive acute lymphocytic leukemia

Abstract

We report the case of a child with acute lymphocytic leukemia with a combination of positive (TEL/AML1 positivity, age, low level minimal residual disease before bone marrow transplantation) and negative (poor prednisone response, high leukocytosis) prognostic features. We used molecular-genetic techniques and flow cytometry for the follow-up of minimal residual disease.

Keywords

• acute lymphocytic leukemia