Abstract
Summary: The authors demonstrate significance od specifical chromosomal aberations for oncogenesis, differential dioagnosis, evaluation of prognosis and detection of minimal residual disease in the Ewing family of tumors (ES). For ES typical translocations are t( 11;22), and t(21;22), infrequently are described t(7;22), t(17;22) and complex translocations.
It is assumed that a fusion protein caused by one of those translocations, in which are connected parts of gene EWS and FL-1, ERG, ETV-1 or EIAF, give rise to this tumor. In addition there are described some secondary chromosomal abbberations.
Increased expression of products of some oncogenes(oncoproteins) c-myc, c -myb and c -mil/c-raf and amplification of c-myc is found in this cancer.