The effect of terlipressin in the prevention on circulatory changes in cmparison with albumin after paracentesis of a tense ascites - randomised multicentric study
Abstract
Circulatory dysfunction is the most serious complication after paracentesis of the ascites. The goal of our study is to compare standard treatment with treatment when terlipresin is added 49 pts were treated by paracentesis due to a tense ascites and were randomized for the treatment with albumin of terlipressin.
In any parameter of hemodynamic changes, no statistically significant difference was demonstrated between two groups, in particular measurements as well as in the development in the course of the first three days after the intervention. Therefore, administration of terlipressin in a dose of 1mg wvery fourth hour was as effective as intravenous albumin in preventing hemodynamic changes in patients with tense ascites treated by paracentesis.