Alprazolam withdrawal and tolerance measured in the social conflict test in mice

Abstract

Tolerance to the alprazolam effects on aggressive and social behaviour developed at different rates suggesting that they are differentially regulated. Furthermore, the evidence of withdrawal responses appearing in a behaviour to which tolerance had not developed does suggest that tolerance and withdrawal phenomena are dissociated in benzodiazepines.

Keywords

• Aggression
• Alprazolam
• Anxiety
• Benzodiazepine
• Tolerance
• Withdrawal