Abstract
We have studied mutagenic or antimutagenic effects of plant compounds on mutagenicity of AFB1 and heterocyclic amines from protein pyrolysate by the Ames and micronucleus tests. Effect of these compounds on immune response in mice was tested by chemiluminescence and blastic transformation tests.
Strong antimutagenic effect against AFB1 was found in cauliflower, carrot and garlic extracts. Extracts from cauliflower and carrot was also able significantly increase extremly low levels of chemiluminescence and blastic transformation, caused by AFB1 and heterocyclic amines from protein pyrolyzate.
Some plant compounds (-angelikalactone, juglone, humulone, emodine, hypericine, psoralene) revealed mutagenic activity. Preliminary results of testing of plant phenol ellagic acid show strong antimutagenic effect against mutagenicity of AFB1 and amino-methylimidazo-quinoline (IQ) in Ames and micronucleus tests