Increased lipolysis in adipose tissue and lipid mobilization to natriuretic peptides during low-calorie diet in obese women
Abstrakt
We recently demonstrated that natriuretic peptides (NP) are involved in a pathway inducing lipolysis in human adipose tissue. Atrial NP (ANP) and brain NP (BNP) operate via a cGMP-dependent pathway which does not involve phosphodiesterase-3B inhibition or CAMP.
The study was performed to evaluate the effect of ANP on lipid mobilization in obese women and secondly to examine the possible effect of a low-calorie diet (LCD) on the lipolytic response of subcutaneous abdominal fat cells to NP and on the lipid mobilization induced by ANP infusion (1 mug/m(2) min for 60 min). CONCLUSION: The present study shows that NP are powerful lipolytic agents in subcutaneous fat cells and that both isoproterenol- and NP-induced lipolysis increase during LCD, in obese women.
These changes seem to be associated with an improvement of the lipolytic pathway at a post-receptor level. Moreover, Lv. administration of ANP induced a lipid mobilizing effect which was enhanced by a LCD in these objects.