The clinical diagnosis of diffuse axonal injury is difficult. The contribution of EEG is evaluated.
The dicisive method is magnetic resonance. The diagnosis can be confirmed unequivocally only post mortem by immunocytochemical examination of tissue samples collected from typically affected areas (corpus callosum, parasagittal subcortical white matter, capsula interna and rostral area of the brain stem).
Most sensitive is the immunocytochemical examination of the beta-amyloid precursor protein.