Abstract
This article presents a review of findings made until now within the experimental treatment of sensitisation mainly on locomotion stimulating effects of opioids in mice and rats and potential neurobiological mechanism of its generation. Sensitisation has been recently one of the main subjects of interest in the research of drug addiction.
Contrary to tolerance, sensitisation is characterised by increased behavioural reaction after repeated administration of a drug. Sensitisation seems to be one of the causes of dependence generation on the opioids and relapse in ex-addict people.
This article presents a review of findings made until now within the experimental treatment of sensitisation mainly on locomotion stimulating effects of opioids in mice and rats and potential neurobiological mechanism of its generation. Most studies focus on the dopaminergic, glutamatergic, gabaergic and serotoninergic receptor systems.
However, none of the tested substances has proved to be ideal for sensitisation treatment. On the other hand, many substances that seem to be ideal in theory were not tested in the experimental treatment.