Publication |
2002
Abstract
Review introduces newer findings on the mode of action of proteases mostly used in clinical treatment. Systemic anti-inflammatory, anti-swelling, and anti-allergic effects (including the brain brain) can be supposed only if relevant proteases cross enteric and blood-brain brain barriers after oral administration, reach the system in detectable amount, and do not loos their enzymatic activity.
Authors summerize findings supporting such a possibility, and point to limitations and further perspectives of the clinical use of proteolytic enzymes.