Antimutagenic Effect of Resveratrol and Diallylsulphide and its Effect on the Immune Response in Mice
Abstract
Using the Ames bacterial mutagenicity test and an in vivo micronucleus test, we investigated the antigenotoxic effect of Resveratrol (RES) and Diallylsulphide (DAS) against the genotoxicity of three mutagens: aminomethylimidazo-quinoline (IQ), aflatoxin B1 (AFB1), and N-nitroso-N-methylurea (MNU). The protective effect of resveratrol and diallyl sulfide was assessed by the chemiluminescence method detecting the production of oxygen radicals, namely the production of the complex of hydrogen peroxide-myeloperoxidase-halid cofactor during phagocytosis, and by the blastic transformation method testing the functional capacity of T-lymphocytes.
In all of the experiments resveratrol and diallyl sulfide to a significant degree repaired the immunosuppressive effects of all three carcinogens tested. Resveratrol and diallyl sulfide demonstrably inhibits the mutagenic activity of three reference mutagens.