Genetic Risk Factors of the Autoimmune Diabetes Mellitus, their Significance and Function

Abstrakt

Pathogenesis of autoimmune diabetes mellitus is activated by genetic and environmental factors. The most important genetic risk factors are the HLA class II. alleles (DQB1*0302,0201; DRB1*0301,0401; DQA1*0301,0501) and the risk alleles of INS-VNTR of promoter region.

Further there are the genetic polymorphisms in some cytokine genes (IL-10, IL-12, IL-18) and the microsatelite polymorphism of MHC class I chain-related gene A (MIC-A).

Klíčová slova

• Genetic
• Factors
• Autoimmune
• Diabetes
• Mellitus
• their
• Significance
• Function