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Cervical lesion's problematic from pathologist's view

Publication at Third Faculty of Medicine |
2004

Abstract

Among the morphological changes of cervical squamous epithelium the most serious is cervical intraepithelial neoplasia (CIN) and squamous carcinoma. According to the stage of affection of epithelium the CIN is divided into three stages.

In this classification it is not necessary to distinguish between CIN III and squamous carcinoma in situ. In the pathogenesis of cervical squamous carcinoma it is often papillomaviral infection which asserts itself.

This carcinoma represents 90% of all cervical carcinomas. Microinvasive carcinoma is determined by maximal invasion depth to 3 mm (measured from epithelium basal membrane) and areal extent to 7 mm.

These criteria apply to all cervical carcinomas. The changes of cervical cylindric epithelium having malignant potential are indicated as cervical glandular intraepithelial neoplasia (CGIN) and it is divided into two stages.

Also in this localisation we do not distinguish between CGIN and carcinoma in situ. The most frequent cervical adenocarcinoma is mucinous ca