Abstract
We report a 46-yars-old woman with chronic HBeAg positive hepatitis B which during ten-years period was successively treated with glucocorticoids and azathioprine, famciclovir, interferon alfa-2a, alfa-2b and natural interferon, lamivudine alone and in combination with natural interferon, but only normal ALT level and HBV DNA negativity in serum were observed after treatment and in no treatment schedule seroconversion of HBeAg to anti-HBe occurred. After long-term lamivudine treatment, a mutant resistant to lamivudine developed with a relapse of hepatitis after therapy cessation.
Finally, we used adefovir dipivoxil 10 mg/day for nine months but again no HBeAg seroconversion occurred. Sustained biochemical and virological response was observed during therapy.
However, after treatment cessation both biochemical and virological relapse recurred