Magnetic resonance relaxometry in monozygotic twins discordant and concordant for schizophrenia

Abstrakt

T1 and T2 relaxation times were examined in four pairs of monozygotic (MZ) twins discordant and concordant for schizophrenia with low and high genetic loading for the illness and five healthy control MZ twin pairs. Patients with schizophrenia (n = 11) showed significant prolongation in T1 relaxation times in the globus pallidus (GP) bilaterally (P < 0.005, Bonferroni corrected) when compared to 144 healthy MZ twins.

Klíčová slova

• MR relaxometry
• Tl relaxation times
• T2 relaxation times
• monozygotic twins
• schizophrenia
• globus pallidus